Endocrine Abstracts

The aim of the present study was to evaluate the potential toxicity of Cefuroxime (CFR), a second-generation cephalosporin antibiotic, on ovary of ‘wistar’ rats. A total of 32 adult female rats (12 weeks old) were intraperitoneally injected with CFR at a dose of 0, 30, 60 or 120 mg/kg, divided into two equal doses daily, for 7 days and sacrificed 24 h after the last dose. Biochemical assays showed significant reduction in oestradiol and progesterone levels in compari...

Imipenem (IMP) is a carbapenem antibiotic mainly used to treat nosocomial infection diseases. We aimed to evaluate the oxidative stress of therapeutic doses of imipenem (IMP) on the ovary of ‘wistar’ rats. In this respect, female rats were divided into four groups: animals were intraperitoneally treated with physiological serum, 30, 50 and 80 mg/kg of IMP for one week. We found that therapeutic doses of this drug did not significantly affect the levels of ovarian mal...